Phenformin: AMP(K)ed for Potential Repurposing
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چکیده
منابع مشابه
Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis. Here, we studied the effects of phenformin, a mitochondrial complex I inhibitor and more potent chemical analog of the diabetes drug metformin on the inhibition of cell growth and induction of apoptosis of glioma stem cells (GSCs) using both in vitro and in vivo models. Phenformin inhibited the self-renewal of GS...
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Since 1956 biguanides have received attention as oral hypoglycaemic agents (Krall and Bradley, 1959). Ungar, Madison, and Carter (1960), using phenformin (Dibotin, phenethyl biguanide), showed their effect on peripheral utilization of glucose, Butterfield, Fry, and Holling (1958) having previously demonstrated increased uptake of insulin in hepatic and peripheral tissues. Since then the drug ha...
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Thirty-eight patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients, however, additional renal or cardiovascular abnormalities, or both, could be identified, which supported a multifactorial aetiology for la...
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Two cases with clinical signs ofpulmonary hypertension and right heart failure developing during phenformin treatment are reported. The patients were clinically improved on withdrawal of phenformin. Two possible explanations for the pulmonary hypertension were considered: cellular anaerobiosis or alphareceptor stimulation of the pulmonary vessels. The 4 patients sofar reported direct attention ...
متن کاملBioassay of phenformin for possible carcinogenicity.
A bioassay of the carcinogenicity of phenformin hydrochloride was conducted using Fischer 344 rats and B6C3F1 mice. The compound was administered in the diet for 78 weeks to groups of 35 animals of each species and sex, using concentrations of 15,000 and 30,000 ppm for rats and concentrations of 1,200 and 2,500 ppm for mice. Treatment was followed by a period of observation of 26 weeks. Control...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2021
ISSN: 0022-202X
DOI: 10.1016/j.jid.2020.06.008